Department of Cytobiochemistry conducts extensive research on the mechanisms of cellular metabolism regulation on the level of enzymes activity and influence of various vitamin B1 derivatives on cell viability.
About the department:
The scope and methodology of the research is concerned with yeast from the genera Malassezia, Candida and Saccharomycesas as well as different cancer cell lines. We conduct analysis of lipid composition, protein comparison and cell viability in different object of our research.
1. Mechanisms of functioning and regulation of key enzymes isolated from animal tissues and yeast.
2. Studies of enzymes derived from the tissues of various animal species in the aspect of adapting their metabolism to environmental conditions.
3. Research on protein and lipid profile of genetic related yeasts.
4. Comparisons of effects of vit. B1 derivatives and mechanisms of their action in different opportunistic yeast cells (Malassezia, Candida) as well as cancer cells.
5. Analysis of lipid and protein composition, of various strains of opportunistic yeast.
Determination of mechanisms of synergistic action of oxitiamine and ketaconazol against opportunistic yeast Malassezia pachydermatis, 1st competition of the National Science Center for financing research projects. NCN, Miniature, project leader: dr Magdalena Siemieniuk, duration: 2017 – 2018.
Characteristic of protein profiles of Malasssezia pachydermatis in the diagnostic aspect using twodimensional electrophoresis, NCN, Preludium, project leader: dr Urszula Czyżewska duration: 2014-2017.
Cooperation with international and Polish scientific institutions:
Department of Pharmaceutical Technology, The Faculty of Pharmacy, Medical University of Bialystok, Poland
Laboratory of cell signalling and metabolic disorders, Nencki Institute of experimental biology, Polish Academy of Sciences, Warsaw, Poland
Laboratory of molecular medical biochemistry, Nencki Institute of experimental biology, Polish Academy of Sciences, Warsaw, Poland
Department of Cellular Signal Transduction, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
Department of Veterinary Mikrobiology, Institute of Biological Bases of Animal Diseases, University of Life Sciences, Lublin, Poland
Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland
GIGA Neurosciences, University of Liege, Liege, Belgium
Belozersky Institute of Physicochemical Biology of Lomonosov Moscow State University, Moscow, Russian Federation
7890B Gas Chromatograph (GC) System, Muse Cell Analyzer, UV-VIS Jasco V-730 speatrophotometer, equipment for cell cultures and basic biochemical analysis
Lectures, laboratories: cell biology, biochemistry, biochemistry of microorganisms, clinical microbiology, food safety and hygiene, food microbiology, plant and animal in vitro cultures, vitaminology, enzymology.
Selected BSc theses:
Perspektywy wykorzystania związku selenu w medycynie/ Perspectives of the use of a selenium compound in medicine.
Homocysteina- jej powstawanie, toksyczność i unieszkodliwianie/ Homocysteine - its formation, toxicity and neutralization.
Azole w terapii przeciwgrzybiczej/ Azole in antifungal therapy.
Selected MSc theses:
Ocena wrażliwości na oksytiamine różnych gatuków z rodzaju Malassezia/ Evaluation of sensitivity to oxitiamine of various species of the genus Malassezia.
Porównanie oddziaływania oksytiaminy i 3-deazotiaminy na komórki raka szyjki macicy/ Comparison of the effects of oxytiamine and 3-deazatiamine on cervical cancer cells.
Analiza śladów lipidowych w ceramice z cmentarzyska z I-V w.n.e w Paprotkach Kolonii, w Krainie Wielkich Jezior Mazurskich/ Analysis of lipid traces in ceramics from a cemetery from I-V century BC in Paprotki Kolonia, in the Land of the Great Masurian Lakes.
Porównanie składu lipidowego mleka różnego pochodzenia./ Comparison of the lipid composition of milk of various origins.
Wyślij je na stronę internetową Wydziału Biologiczno-Chemicznego.