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Research interests:

The recent research work of our Department team has focused on the issue of cell size variation and the impact of this variability on other phenotypic traits of an organisms. We are particularly interested in the relationship between trace elements, cell size and oxidative stress as well as the link connecting the genome mass, cell size and energy metabolism of animals. The results obtained in our laboratories indicate that cell size, through the intensity of apoptosis and proliferation processes, is also a feature that can shape seasonal changes in the body mass of small mammals. No less intriguing are the research conducted in our department  on the borderline of physiology and toxicology, and in particular the role of toxicity of cadmium and other metals in verte- and invertebrates. Currently, as a new project, we are conducting several studies on the relationship between the basal metabolic rate and the probability of developing serious diseases that nowadays constitute the largest percentage of deaths on the globe, including cancer and diabetes.

Research topics:

  1. Evaluation of the mechanisms of the development rate of liver cancer in laboratory mice artificially selected for high and low BMR.
  2. Examination of the mechanisms responsible for the development of insulin resistance and type 2 diabetes in the context of metabolic rate differentiation.
  3. Examination of adaptations of small mammals (bank vole) to seasonal changes in climatic conditions.
  4. Examination of the mechanisms responsible for seasonal changes in body and organ weight in the bank vole.
  5. Examination of the mechanisms of seasonal plasticity of cell size in the bank vole.
  6. The relationship between trace elements, cell size and oxidative stress in the bank vole.

Cooperation with international and Polish scientific institutions:

1. Department of Experimental Pharmacology, Medical University of Białystok, Poland

2. Institute of Environmental Sciences, Jagiellonian University in Kraków, Poland

 

Study:

In the Department of Physiology and Histology weconduct several lectures and laboratories for students of Biology as: Animal’s Physiology, Histology, Developmental Biology, Cell Biology;

 

Selected BSc theses:

Theoretical models of metabolic rate scaling in animals;

Does the Peto paradox solution exist?;

Marihuana –  a medicine or a drug?

Why do we feel pain? - the formation and significance of pain

 

Selected MSc theses:

Development rate of the liver cancer in mice selected for high and low basal metabolic rate.

Cell size and oxidative stress in breeding bank vole females

Head of the Department
Academic Staff
Technicians

Publications
  • Bonda-Ostaszewska E., Włostowski T., Łaszkiewicz-Tiszczenko B., Tissue trace elements and lipid peroxidation in breeding female bank voles Myodes glareolus, Biological Trace Element Research 2018, DOI: 10.1007/s12011-018-1353-7
  • Maciak S., Laboratoria Instytutu Biologii, Laboratorium 2018, 1, 67-72
  • Czarnoleski M., Labecka A.M., Starostová Z., Sikorska A., Bonda-Ostaszewska E., Woch K., Kubička L., Kratochvíl L., Kozlowski J., Not all cells are equal: effects of temperature and sex on the size of different cell types in the Madagascar ground gecko Paroedura picta, Biology Open 2017, 6, 1149-1154, DOI: 10.1242/bio.025817
  • Maciak S., Michalak K., Kale S.D., Michalak P., Nucleolar dominance and repression of 45S ribosomal RNA genes in hybrids between Xenopus borealis and X. muelleri (2n=36), Cytogenetic and Genome Research 2016, DOI: 10.1159/000450665
  • Włostowski T., Kozłowski P., Łaszkiewicz-Tiszczenko B., Oleńska E. - Cadmium accumulation and pathological alterations in the midgut gland of terrestrial snail Helix pomatia L. from a zinc smelter area: role of soil pH, Bulletin of Environmental Contamination and Toxicology 2016, 96, 484-489, DOI: 10.1007/s00128-016-1748-0 [PDF]
  • Michalak K., Maciak S., Kim Y.B., Santopietro G., Oh J.H., Kang L., Garner H.R., Michalak P. - Nucleolar dominance and maternal control of 45S rDNA expression, Proceedings of the Royal Society B - Biological Sciences 2015, 282, 1820, 20152201, http:/dx.doi.org/10.1098/rspb.2015.2201 [PDF]
  • Bonda-Ostaszewska E., Włostowski T. 2015. Apoptosis, proliferation, and cell size in seasonal changes of body and organ weight in male bank voles Myodes glareolus. Mammal Research, DOI: 10.1007/s13364-015-0224-2
  • Maciak S., Michalak P. 2014. Cell size and cancer: a new solution to Peto’s paradox? Evolutionary Applications, doi:10.1111/eva.12228. [PDF]
  • Bonda-Ostaszewska E. 2014. Pomiar biokoncentracji zanieczyszczeń w ocenie skażenia środowiska, narażenia organizmów oraz prognozowaniu ekologicznych efektów zanieczyszczeń. Ekonomia i Środowisko  2(49): 288-297.
  • Włostowski T., Kozłowski P., Łaszkiewicz-Tiszczenko B., Oleńska E., Aleksandrowicz O. 2014. Accumulation of cadmium in and its effect on the midgut gland of terrestrial snail Helix pomatia L. from urban areas in Poland. Bulletin of Environmental Contamination and and Toxicology 93: 526-531. [PDF]
  • Maciak. S., Bonda-Ostaszewska E., Czarnołęski M., Konarzewski M., Kozłowski J. 2014. Mice divergently selected for high and low basal metabolic rates evolved different cell size and organ mass. Journal of Evolutionary Biology, doi: 10.1111/jeb.12306. [PDF]
  • Salińska A., Włostowski T., Oleńska E. 2013. Differential susceptibility to cadmium-induced liver and kidney injury in wild and laboratory-bred bank voles Myodes glareolus. Archives of Environmental Contamination and Toxicology 65: 324-331. [PDF]
  • Salińska A., Włostowski T., Zambrzycka E. 2012. Effect of dietary cadmium and/or lead on histopathological changes in the kidneys and liver of bank voles Myodes glareolus kept in different group densities. Ecotoxicology 21: 2235-2243. [PDF]
  • Bonda-Ostaszewska E., Włostowski T., Krasowska A., Kozłowski P. 2012. Seasonal and photoperiodic effects on lipid droplet size and lipid peroxidation in the brown adipose tissue of bank voles (Myodes glareolus). Acta Theriologica 57: 289-294 [PDF]
  • Salińska A., Włostowski T., Maciak S., Łaszkiewicz-Tiszczenko B., Kozłowski P. 2012. Combined Effect of Dietary Cadmium and Benzo(a)pyrene on Metallothionein Induction and Apoptosis in the Liver and Kidneys of Bank Voles. Biological Trace Element Research 147, 189-194. [PDF]
  • Chwełatiuk E., Włostowski T. 2011. Orally Administered Melatonin and the Accumulation and Toxicity of Cadmium in the Bank Vole (Myodes glareolus). Zoologica Poloniae 56(1-4): 19-33.
  • Maciak S., Kostelecka-Myrcha A. 2011. Regularities of variation of the red blood indices characterizing the respiratory function of blood in fish. Zoologica Poloniae 56(1-4): 35-47.
  • Maciak S., Włostowski T., Salińska A., Bonda-Ostaszewska E. 2011. Tissue Cadmium Accumulation is Associated with Basal Metabolic Rate in Mice. Biological Trace Element Research 144: 944-950 , doi: 10.1007/s12011-011-9061-6. [PDF]
  • Maciak S., Janko K., Kotusz J., Choleva L., Boron A., Juchno D., Kujawa R., Kozłowski J., Konarzewski M. 2011. Standard Metabolic Rate (SMR) is inversely related to erythrocyte and genome size in allopolyploid fish of the Cobitis taenia hybrid complex. Functional Ecology 25: 1072-1078. DOI: 10.1111/j.1365-2435.2011.01870.x. [PDF]
  • Kozłowski J., Czarnołęski M., Francois-Krassowska A., Maciak S., Pis T. 2010. Cell size is positively correlated between different tissues in passerine birds and amphibians, but not necessarily in mammals. Biology Letters DOI: 10.1098/rsbl.2010.0288. [PDF]
  • Włostowski T., Dmowski K., Bonda-Ostaszewska E. 2010. Cadmium accumulation, metallothionein and glutathione levels, and histopathological changes in the kidneys and liver of magpie (Pica pica) from a zinc smelter area. Ecotoxicology 19: 1066-1073. [PDF]
  • Maciak S., Konarzewski M. 2010. Repeatability of standard metabolic rate (SMR) in a small ?sh, the spined loach (Cobitis taenia). Comparative Biochemistry and Physiology, Part A 157: 136-141. [PDF]
  • Włostowski T., Krasowska A., Salińska A., Włostowska M. 2009. Seasonal changes of body iron status determine cadmium accumulation in the wild bank voles. Biol. Trace Elem. Res. 131: 291-297.
  • Włostowski T., Bonda E., Krasowska A. 2008. Effect of cold on lipid peroxidation in the brown adipose tissue and liver of rats. Journal of Thermal Biology 33: 180-184. [PDF]
  • Włostowski T., Krasowska A., Bonda E. 2008. Joint effects of dietary cadmium and polychlorinated biphenyls on metallothionein induction, lipid peroxidation and histopathology in the kidneys and liver of bank voles. Ecotoxicology and Environmental Safety 69: 403-410.
  • Bonda E., Włostowski T., Krasowska A. 2007. Metabolizm i toksyczność kadmu u człowieka i zwierząt. Kosmos 56: 87-97.
  • Włostowski T., Bonda E., Krasowska A. 2006. Free-ranging European bisons accumulate more cadmium in the liver and kidneys than domestic cattle in north-eastern Poland. Science of the Total Environment 364: 295-300.
  • Chwełatiuk E., Włostowski T., Krasowska A., Bonda E. 2006. The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. J. Trace Elem. Med. Biol. 19: 259-265.
  • Włostowski T ., Chwełatiuk E., Bonda E., Krasowska A., Żukowski J. 2005. Hepatic and renal cadmium accumulation is associated with mass-specific daily metabolic rate in the bank vole. Comp. Biochem. Physiol. C 141: 15-19.
  • Chwełatiuk E., Włostowski T., Krasowska A., Bonda E. 2005. Melatonin increases tissue accumulation and toxicity of cadmium in the bank vole (Clethrionomys glareolus). BioMetals 18: 283-291.
  • Bonda E., Włostowski T., Krasowska A. 2004. Testicular toxicity induced by dietary cadmium is associated with decreased testicular zinc and increased hepatic and renal metallothionein and zinc in the bank vole. BioMetals 17: 615-624.
  • Włostowski T., Bonda E., Krasowska A. 2004. Photoperiod affects hepatic and renal cadium accumulation, metallothionein induction, and cadium toxicity in the wild bank vole (Clethrionomys glareolus). Ecotoxicology and Environmental Safety 58: 29-36.
  • Krasowska A., Włostowski T., Bonda E. 2004.Zinc protection from fluoride-induced testicular injury in the bank vole (Clethrionomys glareolus). Toxicology Letters 147: 229-235.
  • Włostowski T., Krasowska A., Bonda E. 2003. An iron-rich diet protects the liver and kidneys against cadmium-induced injury in the bank vole (Clethrionomys glareolus). Ecotoxicol. Environ. Safety 54: 194-198.
  • Włostowski T., Krasowska A., Godlewska-Żyłkiewicz B. 2000. Dietary cadmium decreases lipid peroxidation in the liver and kidneys of the bank vole (Clethrionomys glareolus). J. Trace Elem. Med. Biol. 14: 76-80.
  • Włostowski T., Krasowska A., Łaszkiewicz-Tiszczenko B. 2000. Dietary cadmium induces histopathological changes despite a sufficient metallothionein level in the liver and kidneys of the bank vole (Clethrionomys glareolus). Comp. Biochem Physiol. 126C: 21-28.
  • Włostowski T., Krasowska A. 1999. Subcellular distribution of metallothionein and cadmium in the liver and kidneys of bank voles (Clethrionomys glareolus) exposed to dietary cadmium. Biometals 12: 173-179.
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